Monday, October 20, 2008

Start to the Barcelona Rotation

This blog has been started a little later than planned due to lack of interent access and time constraints.

Renée and I (Teegan) arrived in Barcelona on Friday the 3rd of October, 2008. We arrived at separate times which made signing the lease a little dificult especially since it was all in spanish. The landlords were very nice but did not speak any english so we tried our best to communicate to eachother at the piso though pointing and picture drawing. The flat is much nicer than Renée and I had expected. Everything was very clean and the area around the appartment building is very pretty.

Our first week at SDM (the lab) consisted of reading papers (mostly in spanish) meeting people, and learning how to use all the equipment. SDM is hired by small industrial drug companies to formulate drugs. These small companies do not have the facilities to do so themselves. They try to make formualtions more cost effective while still having the same properties and release profiles as the original formulation. We learned how to preform SeDeM using different excipients. We learned how to determine the angle of repose, bulk density, flowability, tablet compression, etc. At the end of our first week Josep set Renée and I up with our own project to work on for the following month.

In our afternoons we work with Albert and Natalia. We usually follow Albert around and help him make tablets and test them. He taught us how to use Karl Fischer to determine the moisture content of a tablet. We have also been preforming quality control for the tablet formulation he is workin on. Natalia has been showing us how to make disintegrating tablets which have been quite a challenge due to the level of hardness that is desired.

A lot of the concepts we have learned are being reinforced by the laboratory equipment and techniques we use daily in the lab.

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